Development of a medicine to cure gum disease from bitter gourd and pomegranate peel
A combination of bitter gourd and pomegranate peel has opened up a new way to solve the problem of pain and wear caused by severe gum disease (periodontitis). Brazilian scientists have developed a special biomaterial by combining bitter gourd, pomegranate peel juice and the cholesterol-lowering drug simvastatin.
The study, conducted by researchers at the Pontifical Catholic University in São Paulo, Brazil, has been published in the scientific journal ‘Polymer Bulletin’. Severe gum disease gradually destroys the bones and tissues that support teeth, which leads to tooth loosening and loss.
Although currently available treatments reduce infection and swelling, they cannot regenerate the destroyed tissues or bones.
To overcome this limitation, scientists have used bitter gourd. Since the bark of the tree has a strong natural ability to stick (mucoadhesive property), it helps to keep the medicine and natural ingredients stuck to the gums for a long time. This eliminates the need for frequent use of antibiotics. All three ingredients used in this technique have different and important roles.
The bark of the tree acts as a base to keep the medicine stuck to the infected part of the gums for a long time, while the antimicrobial properties of the pomegranate peel juice fight harmful germs and infections in the gums. Similarly, the drug simvastatin reduces swelling and helps in the growth of new bone (osteoinduction).
Since most of this medicine is absorbed by the liver when taken directly as a pill, it would have to be taken in large quantities to reach the gums, which could cause side effects such as muscle weakness. However, when applied directly to the gums through this new gel, even a small amount works safely.
Initial laboratory tests on human stem cells have shown significant improvements in the process of new bone formation within 14 to 21 days of using the gel.
According to Professor Eliana Aparecida de Rezende Duque, coordinator of the research team, this gel made from the bark of the thorn bush, which has not received much attention in medical science until now, could be a revolutionary step in the treatment of teeth and gums in the future.
